Extracellular Signal-regulated Kinase 1/2 Signaling Regulates Cell Invasion:a Review.
10.3881/j.issn.1000-503X.14640
- Author:
Xin-Ying GE
1
;
Lu-Lu SHAO
1
;
Xue-Lin GAO
1
;
Rong-Xia HE
1
Author Information
1. Obstetrics Department of Lanzhou University Second Hospital,The Second Clinical Medical College of Lanzhou University,Lanzhou 730030,China.
- Publication Type:Journal Article
- Keywords:
cancer;
extracellular signal-regulated kinase 1/2;
invasion;
preeclampsia
- MeSH:
Female;
Pregnancy;
Humans;
Mitogen-Activated Protein Kinase 3;
Signal Transduction;
Mitogen-Activated Protein Kinases;
Cell Cycle;
Cell Proliferation
- From:
Acta Academiae Medicinae Sinicae
2023;45(1):155-160
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular signal-regulated kinase 1/2 (ERK1/2) is a serine/threoninekinase involved in the signal transduction cascade of Ras-Raf-mitogen-activated protein kinase (MEK)-ERK.It participates in the cell growth,proliferation and even invasion by regulating gene transcription and expression.The occurrence of a variety of diseases such as lung cancer,liver cancer,ovarian cancer,cervical cancer,endometriosis,and preeclampsia,as well the metastasis and disease progression,is closely associated with the regulation of cell invasion by ERK1/2 signaling pathway.Therefore,exploring the regulation of ERK1/2 signaling on cell invasion and its role in pathogenesis of diseases may help to develop more effective treatment schemes.This article introduces recent progress in the regulation of ERK1/2 signaling on cell invasion and the role of such regulation in diseases,with a view to give new insights into the clinical treatment of ERK 1/2-related diseases.
