Adaptive evolution of microorganisms based on industrial environmental perturbations.
- Author:
Xiaoling TANG
1
;
Jingxiang CHEN
1
;
Zhiqiang LIU
1
;
Yuguo ZHENG
1
Author Information
- Publication Type:Journal Article
- Keywords: adaptive evolution; industrial environmental perturbation; microbial cell factories; production performance; tolerance
- MeSH: Metabolic Engineering; Industrial Microbiology/methods*; Synthetic Biology; Environment; Industry
- From: Chinese Journal of Biotechnology 2023;39(3):993-1008
- CountryChina
- Language:Chinese
- Abstract: The development of synthetic biology has greatly promoted the construction of microbial cell factories, providing an important strategy for green and efficient chemical production. However, the bottleneck of poor tolerance to harsh industrial environments has become the key factor hampering the productivity of microbial cells. Adaptive evolution is an important method to domesticate microorganisms for a certain period by applying targeted selection pressure to obtain desired phenotypic or physiological properties that are adapted to a specific environment. Recently, with the development of technologies such as microfluidics, biosensors, and omics analysis, adaptive evolution has laid the foundation for efficient productivity of microbial cell factories. Herein, we discuss the key technologies of adaptive evolution and their important applications in improvement of environmental tolerance and production efficiency of microbial cell factories. Moreover, we looked forward to the prospects of adaptive evolution to realize industrial production by microbial cell factories.
