Advances in enzyme immobilization based on hierarchical porous metal-organic frameworks.

Author: Yawei CHEN ¹ ; Huijie ZHENG ¹ ; Yiting CAO ¹ ; Jiajia YANG ¹ ; Huiyun ZHOU ¹
Author Information

1. College of Chemical and Pharmaceutical Engineering, Henan University of Science and Technology, Luoyang 471023, Henan, China.
Publication Type:Journal Article
Keywords: biocatalysis; biomedicine; biosensing; hierarchical porous; immobilized enzyme; metal-organic frameworks (MOFs)
MeSH: Metal-Organic Frameworks/chemistry*; Porosity; Enzymes, Immobilized/chemistry*; Biocatalysis; Catalysis
From: Chinese Journal of Biotechnology 2023;39(3):930-941
CountryChina
Language:Chinese
Abstract: As an excellent hosting matrices for enzyme immobilization, metal-organic framework (MOFs) provides superior physical and chemical protection for biocatalytic reactions. In recent years, the hierarchical porous metal-organic frameworks (HP-MOFs) have shown great potential in enzyme immobilization due to their flexible structural advantages. To date, a variety of HP-MOFs with intrinsic or defective porous have been developed for the immobilization of enzymes. The catalytic activity, stability and reusability of enzyme@HP-MOFs composites are significantly enhanced. This review systematically summarized the strategies for developing enzyme@HP-MOFs composites. In addition, the latest applications of enzyme@HP-MOFs composites in catalytic synthesis, biosensing and biomedicine were described. Moreover, the challenges and opportunities in this field were discussed and envisioned.