Advances in physiological activities and synthesis of β-nicotinamide mononucleotide.
- Author:
Yuxian CHEN
1
;
Churan ZHOU
1
;
Jianzhong HUANG
1
;
Yong TAO
2
;
Chongrong KE
1
;
Xinwei YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: 5-phosphoribosyl-1-pyrophosphate; biosynthesis; chemical synthesis; nicotinamide riboside; β-nicotinamide mononucleotide
- MeSH: Nicotinamide Mononucleotide/metabolism*; NAD/metabolism*
- From: Chinese Journal of Biotechnology 2023;39(2):516-536
- CountryChina
- Language:Chinese
- Abstract: Nicotinamide mononucleotide (NMN) is one of the key precursors of coenzyme Ⅰ (NAD+). NMN exists widely in a variety of organisms, and β isomer is its active form. Studies have shown that β-NMN plays a key role in a variety of physiological and metabolic processes. As a potential active substance in anti-aging and improving degenerative and metabolic diseases, the application value of β-NMN has been deeply explored, and it is imminent to achieve large-scale production. Biosynthesis has become the preferred method to synthesize β-NMN because of its high stereoselectivity, mild reaction conditions, and fewer by-products. This paper reviews the physiological activity, chemical synthesis as well as biosynthesis of β-NMN, highlighting the metabolic pathways involved in biosynthesis. This review aims to explore the potential of improving the production strategy of β-NMN by using synthetic biology and provide a theoretical basis for the research of metabolic pathways as well as efficient production of β-NMN.
