Strategies for exogenous RNA delivery in RNAi-mediated pest management.

Liu'e Gong; Shumin Ying; Yafen Zhang; Jiaoyu Wang; Guochang Sun

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Strategies for exogenous RNA delivery in RNAi-mediated pest management.

Author: Liu'e GONG ¹ ; Shumin YING ² ; Yafen ZHANG ¹ ; Jiaoyu WANG ² ; Guochang SUN ²
Author Information

1. College of Life Science, China Jiliang University, Hangzhou 310018, Zhejiang, China.
2. State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang, China.
Publication Type:Journal Article
Keywords: RNA interference; dsRNA delivery; nanoparticle complex; pest management
MeSH: Animals; RNA Interference; Pest Control; Insecta/genetics*; RNA, Double-Stranded; Gene Expression Regulation
From: Chinese Journal of Biotechnology 2023;39(2):459-471
CountryChina
Language:Chinese
Abstract: Plant diseases and insect pests threaten the safety of crop production greatly. Traditional methods for pest management are challenged by the problems such as environmental pollution, off-target effects, and resistance of pathogens and insects. New biotechnology-based strategies for pest control are expected to be developed. RNA interference (RNAi) is an endogenous process of gene regulation, which has been widely used to study the gene functions in various organisms. In recent years, RNAi-based pest management has received increasing attention. The effective delivery of the exogenous interference RNA into the targets is a key step in RNAi-mediated plant diseases and pest control. Considerable advances were made on the mechanism of RNAi, and various RNA delivery systems were developed for efficient pest control. Here we review the latest advances on mechanisms and influencing factors of RNA delivery, summarize the strategies of exogenous RNA delivery in RNAi-mediated pest control, and highlight the advantages of nanoparticle complexes in dsRNA delivery.