Application of self-assembly in polypeptide drugs: a review.

Yue Wang; Xiufang Ding; Sida Zhang; Ruihua Zhang; Dong Chen; Jianfu XU; Long Chen

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Application of self-assembly in polypeptide drugs: a review.

Author: Yue WANG ¹ ; Xiufang DING ¹ ; Sida ZHANG ² ; Ruihua ZHANG ² ; Dong CHEN ² ; Jianfu XU ² ; Long CHEN ¹
Author Information

1. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
2. State Key Laboratory of Nuclear Biological Chemical Protection for Civilian, Beijing 102205, China.
Publication Type:Journal Article
Keywords: drug delivery; drug design; formation mechanism; influencing factor; morphology; peptide self-assembly
MeSH: Pharmaceutical Preparations; Peptides/chemistry*; Amino Acid Sequence; Nanostructures/chemistry*; Drug Delivery Systems
From: Chinese Journal of Biotechnology 2023;39(1):177-191
CountryChina
Language:Chinese
Abstract: Self-assembly refers to the spontaneous process where basic units such as molecules and nanostructured materials form a stable and compact structure. Peptides can self-assemble by non-covalent driving forces to form various morphologies such as nanofibers, nano layered structures, and micelles. Peptide self-assembly technology has become a hot research topic in recent years due to the advantages of definite amino acid sequences, easy synthesis and design of peptides. It has been shown that the self-assembly design of certain peptide drugs or the use of self-assembled peptide materials as carriers for drug delivery can solve the problems such as short half-life, poor water solubility and poor penetration due to physiological barrier. This review summarizes the formation mechanism of self-assembled peptides, self-assembly morphology, influencing factors, self-assembly design methods and major applications in biomedical field, providing a reference for the efficient use of peptides.