Advances of structure and mechanisms of bromodomain-containing protein 4 and its related research in tumors.

Qianhui Huang; Yiyi Ding; Yuwen Tan; Wenxin MO; Tongxin LI; Ying'er Huang; Wenbo Hao

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Advances of structure and mechanisms of bromodomain-containing protein 4 and its related research in tumors.

Author: Qianhui HUANG ¹ ; Yiyi DING ¹ ; Yuwen TAN ¹ ; Wenxin MO ¹ ; Tongxin LI ¹ ; Ying'er HUANG ² ; Wenbo HAO ¹
Author Information

1. School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, Guangdong, China.
2. Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, Guangdong, China.
Publication Type:Journal Article
Keywords: DNA damage checkpoint; bromodomain and extraterminal domain family; bromodomain-containing protein 4; telomere maintenance; transcription factors
MeSH: Humans; Transcription Factors/metabolism*; Nuclear Proteins/metabolism*; Histones; Cell Cycle Proteins/metabolism*; Neoplasms/metabolism*; Protein Domains
From: Chinese Journal of Biotechnology 2023;39(1):132-148
CountryChina
Language:Chinese
Abstract: The bromodomain and extraterminal domain (Bet) family are the regulators of the epigenome and also the pivotal driving factors for the expression of tumor related genes that tumor cells depend on for survival and proliferation. Bromodomain-containing protein 4 (Brd4) is a member of the Bet protein family. Generally, Brd4 identifies acetylated histones and binds to the promoter or enhancer region of target genes to initiate and maintain expression of tumor related genes. Brd4 is closely related to the regulation of multiple transcription factors and chromatin modification and is involved in DNA damage repair and maintenance of telomere function, thus maintaining the survival of tumor cells. This review summarizes the structure and function of Brd4 protein and the application of its inhibitors in tumor research.