Role of N<sup>6</sup>-methyladenosine RNA methylation in central nervous system: a review.

Author: Wanying WANG ¹ ; Fucheng LUO ¹
Author Information

1. State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.
Publication Type:Journal Article
Keywords: N6-methyladenosine (m6A); central nervous system; central nervous system (CNS) diseases; neurodevelopment
MeSH: Methylation; Central Nervous System/metabolism*; RNA, Messenger/metabolism*; RNA
From: Chinese Journal of Biotechnology 2023;39(1):45-59
CountryChina
Language:Chinese
Abstract: There are a variety of post-transcriptional modifications in mRNA, which regulate the stability, splicing, translation, transport and other processes of mRNA, followed by affecting cell development, body immunity, learning and cognition and other important physiological functions. m⁶A modification is one of the most abundant post-transcriptional modifications widely existing in mRNA, regulating the metabolic activities of RNA and affecting gene expression. m⁶A modified homeostasis is critical for the development and maintenance of the nervous system. In recent years, m⁶A modification has been found in neurodegenerative diseases, mental diseases and brain tumors. This review summarizes the role of m⁶A methylation modification in the development, function and related diseases of the central nervous system in recent years, providing potential clinical therapeutic targets for neurological diseases.