Neurophilic herpesvirus: a powerful tool for neuroscience research.

Author: Mingzhi LI ¹ ; Li PAN ² ; Hongxia WU ² ; Huaji QIU ² ; Yimin WANG ¹ ; Yuan SUN ¹
Author Information

1. School of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang 453003, Henan, China.
2. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, Heilongjiang, China.
Publication Type:Journal Article
Keywords: neural circuit; neurological disease; neurotropic herpesvirus; virus tracer
MeSH: Herpesviridae/genetics*; Neurosciences; Genetic Vectors/genetics*; Genetic Engineering; Neurons
From: Chinese Journal of Biotechnology 2023;39(1):7-18
CountryChina
Language:Chinese
Abstract: Viruses are powerful tools for the study of modern neurosciences. Most of the research on the connection and function of neurons were done by using recombinant viruses, among which neurotropic herpesvirus is one of the most important tools. With the continuous development of genetic engineering and molecular biology techniques, several recombinant neurophilic herpesviruses have been engineered into different viral tools for neuroscience research. This review describes and discusses several common and widely used neurophilic herpesviruses as nerve conduction tracers, viral vectors for neurological diseases, and lytic viruses for neuro-oncology applications, which provides a reference for further exploring the function of neurophilic herpesviruses.