Dopamine Transporter Gene Polymorphism Association between ADHD Patients and the Parents Group.
- Author:
Myung Ho LIM
1
;
Sung Hun YU
;
Ki Chung PAIK
;
Soo Churl CHO
;
Hyun Woo KIM
;
Do Young YOON
Author Information
1. Department of Psychiatry, College of Medicine, Dankook University, Cheonan, Korea.
- Publication Type:Original Article
- Keywords:
Attention deficit hyperactivity disorder;
Dopamine transporter gene;
Polymorphism
- MeSH:
Alleles;
Anxiety;
Attention Deficit Disorder with Hyperactivity;
Child;
Child Behavior;
Diagnosis;
Diagnostic and Statistical Manual of Mental Disorders;
DNA;
Dopamine Plasma Membrane Transport Proteins*;
Dopamine*;
Follow-Up Studies;
Humans;
Korea;
Lymphocytes;
Parents*;
Polymerase Chain Reaction
- From:Korean Journal of Psychopharmacology
2003;14(4):347-353
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Attention deficity hyperactive disorder is known to be a disease with a high genetic trait. Recently the relationship between alleles frequency distribution and ADHD has been actively researched. In Korea, the relationship between the genetic type and alleles for dopamine transporter gene has been studied in ADHD patients. METHODS: Thirty five patients diagnosed with ADHD according to the DSM-IV diagnostic criteria were selected for study. The diagnosis and clinical features were confirmed by korean version Child behavior check list, korean version Conner's parent rating scale, Attention deficit Diagnostic System, korean version Spielberger state-trait anxiety scale etc. For the control group, the parents of patients were chosen. Blood samples were taken from the 105 subjects. DNA was extracted from blood lymphocytes, PCR was performed for dopamine transporter gene. RESULTS AND CONCLUSION: In comparing the ADHD transmitted group and the not transmitted group, significant difference was seen between the DAT1 genetic type and alleles distribution. As a result, it is viewed that there is relationship between ADHD and the dopamine transporter gene. Follow up studies with larger patient or pure subgroups are expected.
