Dopamine Transporter Density of the Basal Ganglia as a Predictor of Methylphenidate Response in Children with Attention Deficit Hyperactivity Disorder-A 123IIPT SPECT Study.
- Author:
Hyun Ju HONG
1
;
Young Hoon RYU
;
Kee NAMKOONG
;
Chan Hyung KIM
;
Keun Ah CHEON
;
Hong Shick LEE
Author Information
1. Department of Psychiatry, College of Medicine, Yonsei University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
DAT;
Methylphenidate;
Treatment response;
SPECT
- MeSH:
Basal Ganglia*;
Child*;
Dopamine Plasma Membrane Transport Proteins*;
Dopamine*;
Humans;
Methylphenidate*;
Synaptic Transmission;
Tomography, Emission-Computed, Single-Photon*
- From:Korean Journal of Psychopharmacology
2003;14(4):377-386
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Dopamine transporter is a key regulator of dopamine neurotransmission and is also the primary target of methylphenidate. This study tested the hypothesis that dopamine transporter (DAT) density in basal ganglia is a predictor of favorable methylphenidate (MP) treatment response. METHODS: 15 drug-naive boys with ADHD were included in this study (8 children: treatment responder, 7 children: treatment non responder). They were assessed with psychiatric interview, KEDI-WISC, K-ARS, ADS and CBCL. After then, they were performed [123 I]IPT SPECT. They were evaluated about treatment response after treatment with methylphenidate during 8 weeks. SPECT data reconstructed for the assessment of specific/nonspecific DAT binding ratio of the basal ganglia were compared between treatment responders and nonresponders. RESULTS: There were not significant differences in dopamine transporter density in basal ganglia between the two groups. CONCLUSION: This finding suggests that dopamine transporter density does not mediate the MP treatment response in a direct way.
