Ambient Fine Particulate Matter Exposure and Blood Pressure: Evidence from a Large Chinese Multiple Follow-Up Study.

Bahabaike Jiangtulu; Chang Xin Lan; Jun Xi Chen; Xi Chen; Bin Wang; Tao Xue

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Ambient Fine Particulate Matter Exposure and Blood Pressure: Evidence from a Large Chinese Multiple Follow-Up Study.

Author: Bahabaike JIANGTULU ^{1
,

2} ; Chang Xin LAN ^{1
,

2} ; Jun Xi CHEN ^{1
,

2} ; Xi CHEN ³ ; Bin WANG ^{1
,

2} ; Tao XUE ^{1
,

2}
Author Information

1. Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, China
2. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
3. National Institute of Environmental Health, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China.
Publication Type:Journal Article
Keywords: Blood pressure; Fine particulate matter; PM2.5; Preventive medicine; Risk assessment
MeSH: Middle Aged; Humans; Aged; Particulate Matter/analysis*; Blood Pressure; Air Pollutants/analysis*; Follow-Up Studies; Hypertension/etiology*; East Asian People; Environmental Exposure/analysis*; Air Pollution/analysis*; China/epidemiology*
From: Biomedical and Environmental Sciences 2023;36(1):38-49
CountryChina
Language:English
Abstract: OBJECTIVE:This study aimed to investigate the association of ambient PM_2.5 exposure with blood pressure (BP) at the population level in China.
METHODS:A total of 14,080 participants who had at least two valid blood pressure records were selected from the China Health and Retirement Longitudinal Survey during 2011-2015. Their long-term PM_2.5 exposure was assessed at the geographical level, on the basis of a regular 0.1° × 0.1° grid over China. A mixed-effects regression model was used to assess associations.
RESULTS:Each decrease of 10 μg/m³ in the 1 year-mean PM_2.5 concentration (FPM_1Y) was associated with a decrease of 1.24 [95% confidence interval (CI): 0.84-1.64] mmHg systolic BP (SBP) and 0.50 (95% CI: 0.25-0.75) mmHg diastolic BP (DBP), respectively. A robust association was observed between the long-term decrease in PM_2.5 and decreased BP in the middle-aged and older population. Using a generalized additive mixed model, we further found that SBP increased nonlinearly overall with FPM_1Y but in an approximately linear range when the FPM_1Y concentration was < 70 µg/m³; In contrast, DBP increased approximately linearly without a clear threshold.
CONCLUSION:Efficient control of PM_2.5 air pollution may promote vascular health in China. Our study provides robust scientific support for making the related air pollution control policies.