Progress in omics research and preclinical models of gallbladder cancer.
10.3760/cma.j.cn112139-20220430-00193
- Author:
Ming Jiang YANG
1
;
Ying WU
1
;
Dong Xi XIANG
1
;
Ying Bin LIU
1
Author Information
1. Department of Biliary-Pancreatic Surgery,Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China.
- Publication Type:Journal Article
- MeSH:
Humans;
Gallbladder Neoplasms/genetics*;
Prognosis;
Tumor Microenvironment
- From:
Chinese Journal of Surgery
2023;61(3):260-264
- CountryChina
- Language:Chinese
-
Abstract:
Gallbladder cancer(GBC)is one common type of bile tract cancers with poor prognosis. This review summarizes the recent development of studies about somatic mutation, molecular subtype, microenvironment heterogeneity, organoid, orthotopic model, patient-derived xenograft and clinical translation on GBC in aspects of genomic,transcriptome,single cell omics and clinical translation. We expect this review will provide new ideas on dissecting molecular mechanisms underlying the development and emerging chemoresistance of GBC following therapy and promote GBC precision medicine.
