Current status and thought of transcatheter mitral edge-to-edge repair in the treatment of hypertrophy cardiomyopathy.
10.3760/cma.j.cn112139-20221018-00449
- Author:
Pei Jian WEI
1
;
Feng Wen ZHANG
1
;
Xiang Bin PAN
1
Author Information
1. Department of Structural Heart Disease, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Health Commission Key Laboratory of Cardiovascular Regeneration Medicine, Key Laboratory of Innovative Cardiovascular Devices, Chinese Academy of Medical Sciences, National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Treatment Outcome;
Cardiomyopathy, Hypertrophic/surgery*;
Mitral Valve/surgery*;
Ventricular Septum/surgery*;
Hypertrophy
- From:
Chinese Journal of Surgery
2023;61(3):196-200
- CountryChina
- Language:Chinese
-
Abstract:
Septal reduction therapies, which include septal myectomy and alcohol septal ablation and so on, are the current treatment strategies for patients with obstructive hypertrophic cardiomyopathy and drug-refractory symptoms. With the deepening of theoretical understanding and the rapid development of interventional therapies, some researchers have tried to perform transcatheter mitral valve edge-to-edge repair to treat high-risk patients with hypertrophic cardiomyopathy, including obstructive and non-obstructive. The reported results are relatively satisfactory, but many urgent problems need to be solved, such as the lack of data on animal experiments and large cohort studies, and the unknown medium- and long-term outcomes. However, transcatheter mitral valve edge-to-edge repair brings new ideas for the diagnosis and treatment of patients with hypertrophic cardiomyopathy. On one hand, it can be used as a monotherapy, on the other hand, it can be combined with novel molecular targeted drug therapy or emerging minimally invasive surgical procedures targeting hypertrophic ventricular septum, which deserves our further attention and exploratory research.
