Mechanism of programmed cell death in follicular atresia.
- Author:
Xin WANG
1
;
Yi-Long JIANG
1
;
Ze-Long WANG
1
;
Bo KANG
2
Author Information
1. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
2. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China. bokang@sicau.edu.cn.
- Publication Type:Journal Article
- MeSH:
Female;
Animals;
Follicular Atresia;
Apoptosis;
Cell Death;
Ferroptosis;
Pyroptosis
- From:
Acta Physiologica Sinica
2023;75(1):82-90
- CountryChina
- Language:Chinese
-
Abstract:
Apoptosis and autophagy of follicular granulosa cells play an important regulatory role in the process of ovarian follicular atresia in animals. Recent studies have shown that ferroptosis and pyroptosis are also involved in the process of ovarian follicular atresia. Ferroptosis is a form of cell death caused by iron-dependent lipid peroxidation and reactive oxygen species (ROS) accumulation. Studies have confirmed that autophagy- and apoptosis-mediated follicular atresia also have typical characteristics of ferroptosis. Pyroptosis is a pro-inflammatory cell death dependent on Gasdermin protein, which can regulate ovarian reproductive performance by regulating follicular granulosa cells. This article reviews the roles and mechanisms of several types of programmed cell death independently or interactively regulating follicular atresia, in order to expand the theoretical research on follicular atresia mechanism and provide the theoretical reference for the mechanism of programmed cell death-induced follicular atresia.
