New mechanisms of chronic kidney disease-associated vascular calcification.
- Author:
Pei-Wen WANG
1
;
Ai-Hua ZHANG
2
Author Information
1. Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
2. Xuanwu Hospital of Capital Medical University, Beijing 100053, China. zhangaihua0982@sina.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Osteogenesis;
Renal Insufficiency, Chronic;
Vascular Calcification/pathology*;
Proteins;
Cardiovascular Diseases/complications*;
Disease Progression;
Myocytes, Smooth Muscle
- From:
Acta Physiologica Sinica
2022;74(6):913-926
- CountryChina
- Language:Chinese
-
Abstract:
Vascular calcification is the crucial factor of high cardiovascular disease morbidity and mortality in patients with chronic kidney disease (CKD), which causes a huge medical and economic burden. It is urgent to explore its pathogenesis and intervention methods. CKD-associated vascular calcification is an ectopic osteogenesis process actively regulated by multiple cells. Vascular smooth muscle cells (VSMCs) undergo osteogenic differentiation in a pro-calcification environment, and secrete matrix vesicles to form calcium and phosphorus crystal deposition sites, which are key events in the development of CKD-associated vascular calcification. This article reviews the new mechanism and technology of CKD-associated vascular calcification and discusses the role of the myokine Irisin in CKD-associated vascular calcification.
