Consensus and controversy on research progress and clinical practice of vascular calcification.
- Author:
Hui HUANG
1
;
Ai-Hua ZHANG
2
;
Jing CHEN
3
;
Ling-Qing YUAN
4
Author Information
1. The Eight Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China. huangh8@mail.sysu.edu.cn.
2. Xuanwu Hospital of Capital Medical University, Beijing 100053, China. zhangaihua0982@sina.com.
3. Huashan Hospital, Fudan University, Shanghai 200040, China. chenjing1998@fudan.edu.cn.
4. The Second Xiangya Hospital of Central South University, Changsha 410011, China. allenylq@csu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Humans;
Consensus;
Epigenesis, Genetic;
Vascular Calcification/pathology*;
Cardiovascular Diseases;
Myocytes, Smooth Muscle
- From:
Acta Physiologica Sinica
2022;74(6):859-884
- CountryChina
- Language:Chinese
-
Abstract:
Vascular calcification is an active and complex pathological process regulated by several factors. Vascular calcification is closely related to the incidence and mortality of the cardiovascular disease, chronic kidney disease and other diseases, which affects multiple organs and systems, thus affecting people's health. Therefore, more and more attention is paid to vascular calcification. At present, the pathogenesis and clinical practice of vascular calcification have been continuously improved, which mainly includes calcium and phosphorus imbalance theory, vascular smooth muscle cell transdifferentiation theory, bone homeostasis imbalance theory, epigenetic regulation theory, inflammation theory, extracellular matrix theory, new cell fate theory and so on. However, there are still many unsolved problems. Since the occurrence and development of vascular calcification affect multiple organs and systems, this expert consensus gathered clinicians and basic research experts engaged in the study of vascular calcification in order to summarize the progress of various disciplines related to vascular calcification in recent years. The purpose of this consensus is to systematically summarize the latest research progress, treatment consensus and controversy of vascular calcification from the aspects of epidemiology, pathogenesis, prevention and treatment, so as to provide theoretical basis and clinical enlightenment for in-depth research in this field.
