Integrins in human hepatocellular carcinoma tumorigenesis and therapy.
10.1097/CM9.0000000000002459
- Author:
Qiong GAO
1
;
Zhaolin SUN
1
;
Deyu FANG
2
Author Information
1. College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116044, China.
2. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
- Publication Type:Journal Article
- MeSH:
Humans;
Integrins/metabolism*;
Carcinoma, Hepatocellular/genetics*;
Liver Neoplasms/genetics*;
Cell Adhesion;
Carcinogenesis;
Cell Transformation, Neoplastic;
Tumor Microenvironment
- From:
Chinese Medical Journal
2023;136(3):253-268
- CountryChina
- Language:English
-
Abstract:
Integrins are a family of transmembrane receptors that connect the extracellular matrix and actin skeleton, which mediate cell adhesion, migration, signal transduction, and gene transcription. As a bi-directional signaling molecule, integrins can modulate many aspects of tumorigenesis, including tumor growth, invasion, angiogenesis, metastasis, and therapeutic resistance. Therefore, integrins have a great potential as antitumor therapeutic targets. In this review, we summarize the recent reports of integrins in human hepatocellular carcinoma (HCC), focusing on the abnormal expression, activation, and signaling of integrins in cancer cells as well as their roles in other cells in the tumor microenvironment. We also discuss the regulation and functions of integrins in hepatitis B virus-related HCC. Finally, we update the clinical and preclinical studies of integrin-related drugs in the treatment of HCC.
