Effect of Shugan Tiaoshen acupuncture combined with western medication on depression-insomnia comorbidity due to COVID-19 quarantine: a multi-central randomized controlled trial.
10.13703/j.0255-2930.20221030-k0004
- Author:
Lu-da YAN
1
,
2
,
3
,
4
;
Zhong-Xian LI
5
,
6
;
Yu ZHANG
3
,
4
,
5
;
Xue-Song LIANG
7
,
8
;
Jing-Jing LI
3
,
4
,
5
;
Miao WU
5
,
6
;
Guo-Ao SHI
5
,
6
;
Rui-Ming CHEN
5
,
6
;
Xiang JI
5
,
6
;
Si-Yao ZUO
9
;
Shi-Yun CHEN
3
,
4
,
5
;
Peng ZHOU
3
,
4
,
5
;
Wen-Bin FU
1
,
8
,
10
Author Information
1. Second Clinical Medicine College, Guangzhou University of CM, Guangzhou 510405, Guangdong Province, China
2. Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province
3. Shenzhen Bao'an Research Center for Acupuncture and Moxibustion, Shenzhen 518100, Guangdong Province
4. Shenzhen Government "Medical Health Project", Professor FU Wen-bin's Team of Guangdong Provincial Hospital of TCM, Shenzhen 518100.
5. Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province
6. Shenzhen Bao'an Research Center for Acupuncture and Moxibustion, Shenzhen 518100, Guangdong Province.
7. Shenzhen Government "Medical Health Project", Professor FU Wen-bin's Team of Guangdong Provincial Hospital of TCM, Shenzhen 518100
8. Guangdong Provincial Hospital of TCM, Guangzhou 510120.
9. Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province.
10. Shenzhen Government "Medical Health Project", Professor FU Wen-bin's Team of Guangdong Provincial Hospital of TCM, Shenzhen 518100
- Publication Type:Journal Article
- Keywords:
COVID-19;
acupuncture;
cortical excitability;
depression-insomnia comorbidity;
neuroplasticity;
quarantine
- MeSH:
Humans;
Depression;
Quarantine;
Serotonin;
Sleep Initiation and Maintenance Disorders;
COVID-19;
Acupuncture Therapy;
Comorbidity
- From:
Chinese Acupuncture & Moxibustion
2023;43(3):255-260
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of Shugan Tiaoshen acupuncture (acupuncture for soothing the liver and regulating the mentality) combined with western medication on depression and sleep quality in the patients with depression-insomnia comorbidity due to COVID-19 quarantine, and investigate the potential mechanism from the perspective of cortical excitability.
METHODS:Sixty patients with depression-insomnia comorbidity due to COVID-19 quarantine were randomly divided into an acupuncture group and a sham-acupuncture group, 30 cases in each one. The patients of both groups were treated with oral administration of sertraline hydrochloride tablets. In the acupuncture group, Shugan Tiaoshen acupuncture was supplemented. Body acupuncture was applied to Yintang (GV 24+), Baihui (GV 20), Hegu (LI 4), Zhaohai (KI 6), Qihai (CV 6), etc. The intradermal needling was used at Xin (CO15), Gan (CO12) and Shen (CO10). In the sham-acupuncture group, the sham-acupuncture was given at the same points as the acupuncture group. The compensatory treatment was provided at the end of follow-up for the patients in the sham-acupuncture group. In both groups, the treatment was given once every two days, 3 times a week, for consecutive 8 weeks. The self-rating depression scale (SDS) and insomnia severity index (ISI) scores were compared between the two groups before and after treatment and 1 month after the end of treatment (follow-up) separately. The cortical excitability indexes (resting motor threshold [rMT], motor evoked potential amplitude [MEP-A], cortical resting period [CSP]) and the level of serum 5-hydroxytryptamine (5-HT) were measured before and after treatment in the two groups.
RESULTS:After treatment and in follow-up, SDS and ISI scores were decreased in both groups compared with those before treatment (P<0.05), and the scores in the acupuncture group were lower than those in the sham-acupuncture group (P<0.05), and the decrease range in the acupuncture group after treatment was larger than that in the sham-acupuncture group (P<0.05). After treatment, rMT was reduced (P<0.05), while MEP-A and CSP were increased (P<0.05) in the acupuncture group compared with that before treatment. The levels of serum 5-HT in both groups were increased compared with those before treatment (P<0.05). The rMT in the acupuncture group was lower than that in the sham-acupuncture group, while MEP-A and CSP, as well as the level of serum 5-HT were higher in the acupuncture group in comparison with the sham-acupuncture group (P<0.05).
CONCLUSION:Shugan Tiaoshen acupuncture combined with western medication can relieve depression and improve sleep quality in the patients with depression-insomnia comorbidity due to COVID-19 quarantine, which is probably related to rectifying the imbalanced excitatory and inhibitory neuronal functions.
