Association between physical exercise and non-alcoholic fatty liver disease in people infected with hepatitis B virus.
10.3760/cma.j.cn112338-20220907-00769
- VernacularTitle:HBV感染人群中运动与非酒精性脂肪性肝病的关联性分析
- Author:
Huan Le CAI
1
;
Zhi Cheng DU
1
;
Ying WANG
1
;
Shu Ming ZHU
1
;
Jing Hua LI
1
;
Wang Jian ZHANG
1
;
Jing GU
1
;
Yuan Tao HAO
2
Author Information
1. Department of Medical Statistics, School of Public Health, Global Health Institute, Center for Health Information Research, Sun Yat-sen University, Guangzhou 510080, China.
2. Department of Medical Statistics, School of Public Health, Global Health Institute, Center for Health Information Research, Sun Yat-sen University, Guangzhou 510080, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Female;
Adolescent;
Middle Aged;
Non-alcoholic Fatty Liver Disease/epidemiology*;
Hepatitis B virus;
Risk Factors;
Tobacco Smoke Pollution;
Exercise;
Hypertension
- From:
Chinese Journal of Epidemiology
2023;44(3):445-451
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the association between physical exercise and non-alcoholic fatty liver disease (NAFLD) in people infected with HBV. Methods: The information about the 3 813 participants infected with HBV, including the prevalence of NAFLD, prevalence of physical exercise and other covariates, were collected from the National Science and Technology Major Project of China during 2016-2020. The logistic regression model was used to evaluate the association between physical exercise and NAFLD in HBV infected patients, and subgroup analysis was performed to identify the effect modifiers. Results: A total of 2 259 HBV infected participants were included in the final analysis and 454 (20.10%) had NAFLD. After adjusting for covariates, we found that moderate physical exercise was a protective factor for NAFLD (OR=0.66, 95%CI: 0.46-0.94). Subgroup analysis suggested that the protective effect of moderate physical exercise on NAFLD might be stronger in women (OR=0.61, 95%CI: 0.36-1.01), those <45 years old (OR=0.24, 95%CI: 0.06-0.80), those who had low education level (OR=0.16, 95%CI: 0.04-0.49), those who had low annual income (OR=0.39, 95%CI: 0.16-0.89 for <30 000 yuan RMB; OR=0.64, 95%CI: 0.40-1.00 for 30 000-80 000 yuan RMB), those who had hypertension (OR=0.45, 95%CI: 0.21-0.88), those with BMI ≥24.0 kg/m2 (OR=0.66, 95%CI: 0.43-1.01), those who had more daily fruit or vegetable intake (OR=0.61, 95%CI: 0.38-0.97), those who had more daily meat intake (OR=0.49, 95%CI: 0.23-0.97), and those who had no smoking history (OR=0.66, 95%CI: 0.45-0.95) or passive smoking exposure (OR=0.61, 95%CI: 0.37-0.97). Conclusions: Among HBV infected patients, moderate physical exercise was negatively associated with the prevalence of NAFLD. Women, young people, those who had low education level, those who had low annual income, those with hypertension, those with high BMI, those who had more daily fruit or vegetable and meat intakes, and those who had no smoking history or passive smoking exposure might be more sensitive to the protective effect.
