Research progress of Eubacterium and its metabolite short-chain fatty acids in regulating type 2 diabetes mellitus.
10.3760/cma.j.cn112150-20220302-00195
- Author:
Wei Dong LI
1
;
Li Sha LI
2
;
Mei Jun LYU
1
;
Qiong Ying HU
2
;
Da Qian XIONG
2
Author Information
1. Department of Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
2. Department of Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Diabetes Mellitus, Type 2;
Eubacterium/metabolism*;
Fatty Acids, Volatile/metabolism*;
Gastrointestinal Microbiome
- From:
Chinese Journal of Preventive Medicine
2023;57(1):120-124
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal flora and its metabolites are closely related to the progression of type 2 diabetes mellitus(T2DM). Eubacterium is one of the dominant intestinal flora, and its metabolites short-chain fatty acids (SCFAs) play a leading role in regulating intestinal metabolic balance. It has been reported that SCFAs can regulate the secretion of glucagon-like peptide-1, improve the function of pancreatic β cells, participate in bile acids metabolism and regulate the production of inflammatory factors in T2DM. Based on the above research background, this article mainly reviews the relationship between Eubacterium and its metabolite SCFAs and T2DM and its regulatory mechanism.
