Implementation and quality control of human immunodeficiency virus laboratory diagnosis strategy.
10.3760/cma.j.cn112150-20220517-00497
- Author:
Yuan Fang WANG
1
;
Dong Dong LI
1
;
Yi XIE
1
Author Information
1. Department of Laboratory Medicine,Westchina Hospital of Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Humans;
HIV;
HIV Infections/diagnosis*;
Sensitivity and Specificity;
Clinical Laboratory Techniques/methods*;
Quality Control
- From:
Chinese Journal of Preventive Medicine
2023;57(1):1-7
- CountryChina
- Language:Chinese
-
Abstract:
The laboratory diagnostic strategy for human immunodeficiency virus (HIV) is a process to accurately detect HIV patients through a combination of available HIV tests. Laboratory tests for HIV infection are mainly serological antibody and antigen testing and HIV RNA testing. With the update of testing reagents, the sensitivity and specificity have improved substantially and the window period of detection has shortened, but there is a risk of false positives. Various guidelines have recommended different diagnostic strategies for different target populations and different prevalence regions to guide patients to confirm the diagnosis and receive standardized antiretroviral therapy as early as possible. How to refer to the diagnostic strategies, reduce false positives and shorten the window period while increasing the detection rate is an urgent issue for laboratories to address. This article describes the characteristics and advantages and disadvantages of testing methods related to HIV infection from the perspective of laboratory diagnostic strategies, as well as the impact of the development of treatments on diagnostic strategies, in order to provide theoretical support for the practical application of HIV diagnostic strategies.
