Infection of human papillomavirus and head and neck cancer.
10.3760/cma.j.cn112152-20211130-00884
- Author:
Cheng SONG
1
;
Shao Kai ZHANG
2
;
You Lin QIAO
1
Author Information
1. Center for Global Health, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
2. Department of Cancer Epidemiology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China.
- Publication Type:Journal Article
- Keywords:
Epidemiology;
HPV positivity;
Head and neck neoplasms;
Human papillomavirus
- MeSH:
Female;
Humans;
Human Papillomavirus Viruses;
Papillomavirus Infections/prevention & control*;
Uterine Cervical Neoplasms/complications*;
Nasopharyngeal Neoplasms/complications*;
Head and Neck Neoplasms/epidemiology*;
Oropharyngeal Neoplasms/epidemiology*;
Papillomaviridae
- From:
Chinese Journal of Oncology
2023;45(1):39-43
- CountryChina
- Language:Chinese
-
Abstract:
High-risk human papillomavirus (HPV)-related cancers consist of cervical cancer, anal cancer, penile cancer, vulvar cancer, vaginal cancer, and head and neck cancer (HNC). Of these, the disease burden of HNC is second only to cervical cancer. HNC mostly originates from malignant lesions of squamous epithelial cells and mainly includes oral cavity cancer, pharyngeal cancer (including nasopharyngeal cancer, oropharyngeal cancer, and hypopharyngeal cancer), and laryngeal cancer. Tobacco use, alcohol abuse, and HPV infection are three primary risk factors. Recently, there is an upward trend of HNC incidence globally, especially in high-income countries. In China, the disease burden and trends of HPV-related HNC are still not clear. A few small sample size and single-center studies suggest a high HPV prevalence and increasing trend in HNC. Methodological differences in HPV testing and regional variabilities still exist among these studies. Among the anatomic sites, oropharyngeal cancer has been shown to be caused by HPV infection, but the association of HPV with other sites is still under debate. In addition, there is a paucity of relevant studies. Here, this review narrates the association between HPV infection and HNC, compares the differences between global and Chinese studies, and then explores the importance of HPV infection in various anatomical sites. The main objective is to highlight the research on HPV-related HNC and promote relevant prevention and treatment programs.
