Role of interleukin-6 signaling pathway in adverse health effects induced by air pollution
- VernacularTitle:白细胞介素-6信号通路在空气污染致不良健康效应中的作用
- Author:
Wenpu SHAO
1
;
Renzhen PENG
1
;
Yanyi XU
1
Author Information
- Publication Type:Review
- Keywords: air pollution; interleukin-6; signaling pathway; respiratory system; toxicological effect; molecular mechanism
- From: Journal of Environmental and Occupational Medicine 2023;40(3):355-361
- CountryChina
- Language:Chinese
- Abstract: Air pollution is one of the most important environmental issues in China and worldwide, as well as a critical public health problem affecting human health. With the implementation of emission reduction and other programs, the air quality in China has been improved dramatically in recent years, but is still worse than the WHO guideline recommended levels. Numerous epidemiological and toxicological studies have shown that short-term or long-term exposure to air pollution is strongly associated with respiratory diseases, cardiovascular diseases, diabetes, and so forth, in which interleukin-6 (IL-6), a well-known inflammatory factor, may play an important role. Studies have found that IL-6 can bind to interleukin-6 receptor (IL-6R) , which leads to the recruiting and activation of glycoprotein 130, and then the formed IL-6/IL-6R/gp130 complex triggers the janus kinase/signal transducer and activator of transcription, Src homology-2 domain-containing protein tyrosine phosphatase-2/mitogen-activated protein kinase, and phosphatidylinositol 3-kinase/protein kinase B signaling pathways. All of these signaling pathways are found to be involved in a variety of physiopathological processes. In the present review, information about the IL-6 signaling pathway and its role in air pollution-induced adverse health effects was systematically reviewed, hoping to provide insights for the future prevention and control policies.
