Chinese Medicine Monomers Against Pancreatic Cancer： A Review
10.13422/j.cnki.syfjx.20230622
- VernacularTitle:中药单体抗胰腺癌研究进展
- Author:
Huimin LI
1
;
Yan LI
1
;
Jiexin CHEN
1
;
Yuqing ZHAO
2
;
Qiuhong WANG
1
Author Information
1. Guangdong Engineering Technology Research Center for Standardized Processing of Chinese Materia Medica， School of Traditional Chinese Medicine， Guangdong Pharmaceutical University， Guangzhou 510006， China
2. Key Laboratory of Northern Medicine Foundation and Application under Ministry of Education， Heilongjiang Key Laboratory of Traditional Chinese Pharmacodynamic Material Base， Heilongjiang University of Chinese Medicine， Harbin 150040， China
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
pancreatic cancer;
pathways;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(10):245-253
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is a disease with a high fatality rate， with a five-year survival rate of no more than 10% and a significantly increasing annual mortality rate. The common pathogenesis factors of pancreatic cancer are family inheritance， diet， pancreatitis， obesity， etc.， among which， family inheritance of pancreatic cancer is the main reason， and about 7%-10% of patients have family inheritance. Surgery is an effective way to treat pancreatic cancer in patients and improve their survival， but most people are diagnosed with pancreatic cancer at intermediate and advanced stages and lose the opportunity for surgical treatment. Therefore， radiotherapy， interventional therapy， supportive treatment， immunotherapy， and other treatments are used clinically to relieve symptoms and prolong the survival of patients. The commonly used clinical drug is gemcitabine. Although it can inhibit tumor growth and improve the condition， it can bring side effects such as bone marrow suppression， rash， digestive tract side effects， and drug resistance. The damage of these side effects to the human body is systemic. Chinese medicine can be used alone or in combination with other treatment methods to reduce the toxic and side effects of chemotherapy， restore the physical energy of patients， and reduce its related complications. Chinese medicine contains a large number of active ingredients， including alkaloids， flavonoids， saponins， phenolic acids， and organic acids， with anti-inflammatory， anti-viral， anti-tumor， and other curative effects. Many clinical studies of traditional Chinese medicine （TCM） on cancers have verified that TCM plays a positive role in tumor prevention and treatment， especially in improving and controlling clinical symptoms， and also plays a good detoxification effect on radiotherapy and chemotherapy， with good results achieved in improving bone marrow suppression， improving immunity， improving quality of life， and prolonging survival. This paper reviewed the anti-pancreatic cancer mechanism of Chinese medicine monomers based on literature in China and abroad， aiming to provide new potential drug candidates for the treatment of pancreatic cancer.
