Role of Aquaporins in Heart Failure from Theory of Cardiac and Renal Coordination
10.13422/j.cnki.syfjx.20231398
- VernacularTitle:基于“心肾相关”探讨水通道蛋白在心衰中的作用
- Author:
Peirong QU
1
;
Jun HU
1
;
Lanchun LIU
1
;
Zhilin JIANG
1
;
Jie WANG
1
Author Information
1. Guang'anmen Hospital， China Academy of Chinese Medical Sciences， Beijing 100053， China
- Publication Type:Journal Article
- Keywords:
theory of cardiac and renal coordination;
aquaporin （AQP）;
heart failure;
heart water
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(10):216-223
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure refers to a group of clinical syndromes caused by structural or functional abnormalities of the heart that lead to impaired ejection or filling of the ventricles. The traditional Chinese medicine （TCM） theory of cardiac and renal coordination holds that the kidney governs water and plays a key role in maintaining the balance of fluid metabolism. Therefore， the treatment of water retention in heart failure can start from the heart and kidney. The basic pathogenesis of heart failure is kidney deficiency， blood stasis， and water stagnation， and the therapies including dredging the heart and kidneys， warming yang and excreting water， tonifying kidneys and activating blood， and dredging meridians and collaterals. Aquaporins （AQPs）， the key molecular basis of water metabolism， are involved in the pathogenesis of water retention in heart failure together with the arginine vasopressin system （AVP）， renin-angiotensin-aldosterone system （RAAS）， and diuretic resistance. Studies have shown that herbal medicines that regulate the heart and kidney can alleviate water retention in heart failure by targeting AQPs， thereby delaying or even reversing the progression of heart failure. This paper expounds the TCM name and pathogenesis of heart failure from the theory of cardiac and renal coordination， the role of AQPs in the pathogenesis of water retention in heart failure， and the modern connotation of the therapy of tonifying heart and kidney for heart failure， aiming to provide ideas for the prevention and treatment of water retention in heart failure by TCM.
