Effect of Continuous Dopaminergic Stimulation on Non-motor Symptoms in Patients with Parkinson's Disease
- VernacularTitle:持续性多巴胺能刺激对帕金森病非运动症状作用的前瞻性研究
- Author:
Tao FENG
;
Xuan ZHANG
;
Ping LIU
;
Yongjun WANG
- Publication Type:Journal Article
- Keywords:
Parkinson's disease, levodopa, non-motor, entacopone
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(10):918-920
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of continuous dopaminergic stimulation on the non-motor symptoms. Methods Fifty-eight patients with Parkinson's disease(PD) following motor fluctuation and non-motor symptom were enrolled in this study. The subjects were treated with levodopa/carbidopa and entacopone for eight weeks. The scores of NMSS, PD fatigue scale, HAMD and Pittsburgh Sleep Quality Index (PSQI) were compared between baseline and endpoint.Results The total scores of NMSS decreased significantly from baseline to endpoint (P<0.05). The scores of endpoint were significantly lower than those of baseline in the urinary, sexual function, depression/anxiety and sleep/fatigue subscale of NMSS; however, there was no significant difference between baseline and endpoint in the gastrointestinal, cardiovascular, hallucination/delusions, attention/memory subscales of NMSS. The scores of endpoint were significantly lower than those of baseline in HAMD, PD fatigue scale and PSQI.Conclusion The continuous dopaminergic stimulation treatment with levodopa/carbidopa and entacapone may improve some respects of non-motor symptom of PD.
