Advance in Damage Mechanism on Blood Brain Barrier after Cerebral Ischemia-reperfusion and Neuroprotective Drugs (review)
- VernacularTitle:脑缺血再灌注后血脑屏障损伤机制及药物保护作用的研究进展
- Author:
Lei LI
;
Dongming XU
;
Wen WANG
;
Peichang WANG
;
Houxi AI
;
Li ZHANG
;
Lin LI
- Publication Type:Journal Article
- Keywords:
cerebral ischemia-reperfusion, blood brain barrier, drug, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(10):901-904
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia-reperfusion Results in breakdown on construction and function of blood brain barrier, leading to hemorrhage transformation and brain edema. At the same time, generous cytokines and chemokines released after cerebral ischemia-reperfusion can regulate the opening of the blood brain barrier. Many current studies showed that the major damage mechanisms on blood brain barrier are inflammatory infiltration, proteolysis, opening aquaporin and so on. The deep research on the mechanism contributes to explore new neuroprotective drugs, and further identify the target and therapeutic effect of drug treatment.
