Effect of Different Doses Methylprednisolone Combined with Monosialotetrahexosyl Ganglioside on Experimental Spinal Cord Injury
- VernacularTitle:不同剂量甲泼尼龙与神经节苷脂联合治疗实验性脊髓损伤
- Author:
Yuyu LUO
;
Xiaodong LI
;
Wencheng ZHANG
- Publication Type:Journal Article
- Keywords:
methylprednisolone, monosialotetrahexosyl ganglioside(GM-1), spinal cord injury
- From:
Chinese Journal of Rehabilitation Theory and Practice
2008;14(8):701-702
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the treatment effect of different doses methylprednisolone(MP)combined with monosialotetrahexosyl ganglioside(GM-1)on experimental spinal cord injury.Methods Based on the duplication of compressed spinal cord animal model,36 rats were divided into three groups randomly:the first group with high dose of MP,the second with moderate dose of MP and GM-1,the third with low dose of MP and GM-1.The motor evoked potential(MEP)and the grades of BBB were detected on the 7th day and 14th day after injury.Results The peak latencies and the amplitudes of MEP and the BBB grades changed significantly after injury in the three groups.After treatment by different administration,the recovery of the two combined groups was more obvious than that of the high dose MP group,and the effect with the low dose of MP and GM-1 group was most significant.Conclusion The treatment effect of low dose MP combined with GM-1 is better than the other two therapies on experimental spinal cord injury.
