Potentials of Immunonutrition in Wound Healing: A Review (Potensi Imunonutrisi dalam Penyembuhan Luka: Tinjauan)
http://dx.doi.org/10.17576/JSKM-2022-2002-03
- Author:
WEI BOON YAP
1
;
NUR FARHANA AZIZAN
2
;
ELYNNA AZURA HSNOL
2
;
KAVIPRIYA KRISHNAN
2
;
SIVANESAN RAJESWARAN
3
;
JIA YIN CHOW
3
;
NORAIHAN IRWAN
3
;
PAVITRA INDRAJOTH
3
;
PRAMILA MANI MARAN
3
;
MUNIRAH ISMAIL
4
Author Information
1. Biomedical Science Program Center for Toxicology and Health Risk Studies Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
2. Master of Health Science (Public Health Nutrition) Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
3. Master of Health Science (Clinical Nutrition) Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
4. Dietetics Program and Center for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
- Publication Type:Journal Article
- Keywords:
Wound healing;
immunonutrition;
PUFAs;
amino acids;
vitamins
- From:Malaysian Journal of Health Sciences
2022;20(No.2):23-33
- CountryMalaysia
- Language:English
-
Abstract:
A delayed wound healing process can lead to detrimental complications in chronic wound patients such as tissue
necrosis and systemic infections. Application of immunonutrition (IN) in experimental animal models and chronic
wound patients has shown promising and improved wound healing processes. IN restores the supply of essential nutrients
that are critical for cell growth and tissue repair in the wounded subjects. Several commonly found nutrients in IN
formulations include polyunsaturated fatty acids (PUFAs), essential amino acids, trace elements such as zinc and
vitamins. Recently, some studies suggested the use of traditionally used herbs like curcumin in IN recipes due to its
efficient wound healing properties. The roles and functions of IN in wound healing encompass recruitment of white
blood cells, platelets and fibroblasts into the wounded area during the coagulation and inflammation phases, enhancement
of fibroblast proliferation, collagen synthesis and neovascularization in the proliferation phase; and lastly, regulation
of tissue re-epithelization for wound closure and recovery. In this review, the roles and functions of individual nutrients
were deliberately discussed alongside their mechanisms of action in wound healing. This aims to provide a more holistic
insight into the potentials of those nutrients when used as part of IN for major wound patients. Despite its remarkable
effects in wound healing, several criteria should be considered in an IN formulation: the type and severity of wounds,
administration timing and mode of administration, and concoction of immune-boosting nutrients in order to ensure the
optimal wound healing effects.
- Full text:14.2022my0416.pdf
