The Analysis of Factors Related to Reaching to Therapeutic Range in Patients with Receiving Therapeutic Hypothermia after Return of Spontaneous Circulation after Out-of hospital Cardiac Arrest.
- Author:
Jae Jin RYOU
1
;
Jin Joo KIM
;
In Cheol HWANG
;
Jin Seong CHO
;
Yong Su LIM
;
Hyuk Jun YANG
;
Keun LEE
Author Information
1. Department of Emergency Medicine, Gachon University Gil Medical Center, Incheon, Korea. empearl@gilhospital.com
- Publication Type:Original Article
- Keywords:
Induced hypothermia;
Heart arrest;
Vasoactive drug;
Outcome
- MeSH:
Heart Arrest*;
Humans;
Hypothermia*;
Hypothermia, Induced;
Mortality;
Multivariate Analysis;
Obesity;
Out-of-Hospital Cardiac Arrest;
Retrospective Studies;
Smoke;
Smoking
- From:Journal of the Korean Society of Emergency Medicine
2015;26(6):526-533
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The relationship between prognostic factors and outcomes of post-cardiac arrest patients treated with therapeutic hypothermia was analyzed. METHODS: We conducted a tertiary center retrospective study of post-cardiac arrest patients treated with therapeutic hypothermia between January 2008 and December 2012. We investigated the association of the following factors with outcomes: BMI, time to ROSC, number of vasoactive drugs, smoking, alcohol, and short time to therapeutic range in hypothermia. RESULTS: A total of 251 patients were enrolled in this study. Large number of vasoactive drugs was a prognostic factor of 3-month mortality (adjusted OR 1.96, 95% CI:1.41-2.71, p<0.001). Obesity (BMI> or =25 kg/m2) was not associated with delayed time to therapeutic range in hypothermia. Both univariate and multivariate analysis showed that high initial BT (beta(SE)=63.64 (11.53), p<0.001) and a small number of vasoactive drugs (beta(SE)=18.66(8.74), p=0.034) were independent predictors of delayed time to therapeutic range in hypothermia. CONCLUSION: In this study, a small number of vasoactive drugs showed a significant influence on delayed time to therapeutic range in patients receiving therapeutic hypothermia after return of spontaneous circulation after out-of-hospital cardiac arrest.
