Effects of Repeated Dosing of 6% Hydroxyethyl Starch or 7.5% Sodium Chloride on Inflammatory Response and Oxidative Damage in Experimental Intracerebral Hemorrhage Rats
- VernacularTitle:多次给予羟乙基淀粉或高渗氯化钠溶液对实验性脑出血大鼠局部氧化损伤和炎性反应的影响
- Author:
Yuming PENG
;
Lixin AN
;
Baoguo WANG
- Publication Type:Journal Article
- Keywords:
hydroxyethyl starch, saline solution, hypertonic, cerebral hemorrhage, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), superoxide dismutase (SOD), malondialdehyde (MDA)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(9):838-840
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of repeated dosing of 6% hydroxyethyl starch (130/0.4) or 7.5% sodium chloride on brain edema after experimental intracerebral hemorrhage (ICH) in rats. Methods 167 male SD rats were divided into four groups randomly: Sham operation group (S, n=20), ICH control group (M, n=38), 7.5% sodium chloride group (N, n=55) and 6% hydroxyethyl starch group (H, n=54). The model of the ICH was established with stereotactically infusing 50 μl of the autologous femoral artery blood into the right caudate nucleus. group N and group H received 7.5% sodium chloride 5 ml/kg and 6% hydroxyethyl starch 30 ml/kg at 2 h, 24 h, 48 h and 72 h after operation respectively. The tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), superoxide dismutase (SOD) and malondialdehyde (MDA) in the tissue around the hemorrhage were measured at different time point. Results The IL-6 in group N was significantly more than that in group M at 24 h and 72 h after infusion (P<0.05), and the TNF-α in group H was less than that in group M at 24 h and 48 h after infusion (P<0.05). The SOD in group M decreased to the bottom at 48 h and 72h after ICH. SOD in group N and group H at 24 h, 48 h and 72 h after infusion was both significant more than that in group M (P<0.05). MDA in group H at 72 h after infusion was less than that in group M (P<0.05). Conclusion Repeated infusion of 6% hydroxyethyl starch (130/0.4) or 7.5% sodium chloride can decrease inflammatory response of brain tissue after ICH, which may protect brain from oxidative damage.
