Relationship between Expression of p75 Gene and Apoptosis of Cerebrum Cells in Type 2 Diabetic Rats
- VernacularTitle:p75基因与2型糖尿病大鼠脑细胞凋亡相关性研究
- Author:
Fengyun REN
;
Canhua ZONG
;
Xiufang LV
;
Xinmin GUO
- Publication Type:Journal Article
- Keywords:
type 2 diabetic rat, p75 gene, apoptosis
- From:
Chinese Journal of Rehabilitation Theory and Practice
2008;14(6):533-534
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between expression of p75 gene and apoptosis of cerebrum cells in type 2 diabetic rats.Methods Ten type 2 diabetic rats and ten natural rats were used to test the expression of brain p75 mRNA by RT-PCR technique, and the apoptosis of cerebrum cells was measured by agarose gel electrophoresis (AGA).Results The expression of brain p75 mRNA and apoptosis of cerebrum cells in type 2 diabetic rats were higher than that of the natural group.Conclusion The apoptosis of cerebrum cells in type 2 diabetic rats increases, and it is positively correlated with the expression of brain p75 gene mRNA.
