Effect of Flurbiprofen Axetil Combined with Fentanyl in Postoperative Patient-controlled Analgesia after Craniotomy

VernacularTitle:氟比洛芬酯复合芬太尼用于颅脑手术后患者自控镇痛的临床观察
Author: Hao CHENG ; Feng XIAO ; Xu JIN ; Ruquan HAN
Publication Type:Journal Article
Keywords: flurbiprofen, fentanyl, patient-controlled analgesia
From: Chinese Journal of Rehabilitation Theory and Practice 2008;14(6):513-514
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect and side effects of flurbiprofen axetil combined with fentanyl in postoperative patient-controlled analgesia (PCA) after craniotomy.Methods 60 patients undergoing scheduled craniotomy were randomly divided into the treatment group and control group with 30 cases in each group, and received flurbiprofen axetil combined with fentanyl and only fentanyl respectively in PCA after craniotomy. The visual analogue scale (VAS), sedation score (SS) and the side effects were evaluated in 24 h after craniotomy.Results There was no significant difference in VAS between the two groups ( P>0.05). The SS, side effects such as nausea and vomiting in the treatment group were significantly less than that in the control group ( P<0.05).Conclusion Flurbiprofen axetil combined with fentanyl in PCA can reduce the side effects of fentanyl and offers overall favorable analgesic responses.