Changes of MEP and Neurologic Function after Erigeron beviscapus Preconditioning on Spinal Cord Ischemia-reperfusion Injury in Rabbits
- VernacularTitle:灯盏细辛预处理脊髓缺血再灌注损伤后动作诱发电位和神经功能的变化
- Author:
Bin CHENG
;
Zhanao GAO
;
Lei WANG
;
Xin WANG
;
Kaifei WANG
- Publication Type:Journal Article
- Keywords:
Erigeron beviscapus, spinal cord, ischemia-reperfusion injury, motor-evoked potential, rabbits
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(8):708-710
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of MEP(motor evoked pontential) and neurologic function after Erigeron beviscapus(EBHM) preconditioning on spinal cord ischemia-reperfusion injury in rabbits, and provide substructural experimental theory.Methods Twenty-four domestic rabbits were randomly divided into four groups with six rabbits each. In sham group (group A) only the abdominal aorta was exposed. In the blank group (group B), the abdominal aorta was occluded 40 minute followed by reperfusion. In the methylprednisolone group (group C), it was occluded 30 minute before the abdominal, methylprednisolone (30 mg/kg) was injected into the rabbit by vein, which was used for two days after the surgeon. In the EBHM group (group D), EBHM(50 mg/kg) was injected into the rabbit by vein, the following procedure was the same as group C. MEP was measured in each observed point and neurologic function was observed everyday for 7days.Results At every observed point after SCI, the MEP changed regularly, and compared with group B, there was significant difference in groups C and D(P<0.05). 7 days later, the neurologic function changed significantly in each group(P<0.05).Conclusion MEP monitoring can reflect the early change on spinal cord ischemia-reperfusion injury. EBHM preconditioning can protect the rabbit from spinal cord ischemia reperfusion injury.
