Peripheral N-methyl-D-aspartate Receptors Involved in Long-term Hyperalgesia Induced by Peripheral Injection of Formalin in Rats
- VernacularTitle:外周N-甲基-D-天门冬氨酸受体在福尔马林外周注射引起长时程痛敏中的作用
- Author:
Juan CHENG
;
Ce ZHANG
- Publication Type:Journal Article
- Keywords:
long-term hyperalgesia, formalin test, microglia, N-methyl-D-aspartate (NMDA) receptors, MK-801, OX-42, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2009;15(7):625-627
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of peripheral N-methyl-D-aspartate (NMDA) receptors in the long-term hyperalgesia induced by peripheral injection of formalin in rats. Methods Formalin was injected in the paws of the SD rats with or without the MK-801 pre-injection. OX-42 expressions in the dorsal horn were observed, and the paw withdrawal thermal latency was measured. Results The OX-42 expression decreased and the paw withdrawal thermal latency prolonged in rats with MK-801 pre-injection. Conclusion Peripheral NMDA receptors may be involved in the long-term hyperalgesia.
