Antioxidation and anti-inflammatory effects of gamma-irradiated silk sericin and fibroin in H 2O2-induced HaCaT Cell
10.4196/kjpp.2023.27.1.105
- Author:
Ji-Hye CHOI
1
;
Sangmin LEE
;
Hye-Ju HAN
;
Jungkee KWON
Author Information
1. Department of Laboratory Animal Medicine, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea
- Publication Type:Original Article
- From:The Korean Journal of Physiology and Pharmacology
2023;27(1):105-112
- CountryRepublic of Korea
- Language:English
-
Abstract:
Oxidative stress in skin cells can induce the formation of reactive oxygen species (ROS), which are critical for pathogenic processes such as immunosuppression, inflammation, and skin aging. In this study, we confirmed improvements from gamma-irradiated silk sericin (I-sericin) and gamma-irradiated silk fibroin (I-fibroin) to skin cells damaged by oxidative stress. We found that I-sericin and I-fibroin effectively attenuated oxidative stress-induced ROS generation and decreased oxidative stress-induced inflammatory factors COX-2, iNOS, tumor necrosis factor-α, and interleukin-1β compared to the use of non-irradiated sericin or fibroin. I-sericin and Ifibroin effects were balanced by competition with skin regenerative protein factors reacting to oxidative stress. Taken together, our results indicated that, compared to non-irradiated sericin or fibroin, I-sericin, and I-fibroin had anti-oxidation and antiinflammation activity and protective effects against skin cell damage from oxidative stress. Therefore, gamma-irradiation may be useful in the development of cosmetics to maintain skin health.
