4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing
10.1186/s40902-022-00334-w
- Author:
Seong-Gon KIM
1
Author Information
1. Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Jibyun-dong, Gangneung, Gangwondo, 28644, Republic of Korea
- Publication Type:Review
- From:Maxillofacial Plastic and Reconstructive Surgery
2022;44(1):5-
- CountryRepublic of Korea
- Language:English
-
Abstract:
4-Hexylresorcinol (4HR) is amphiphilic organic chemical and auto-regulator for micro-organism. As 4HR administration induces the stress on the endoplasmic reticulum, 4HR changes protein folding. The application of 4HR inhibits NF-κB signal pathway and TNF-α production. In addition, 4HR administration increases VEGF, TGF-β1, and calcification associated proteins. As a consequence, 4HR administration increases angiogenesis and bone formation in wounded area. Strong anti-inflammatory reaction and capillary regeneration in diabetic model demonstrate that 4HR can be applied on many types of surgical wound.
