Prenatal Diagnosis of Wilms Tumor.
- Author:
Mi Jung KIM
1
;
Eun Jin CHOI
;
Haeng Mi KIM
;
Kun Soo LEE
Author Information
1. Department of Pediatrics, Kyungpook National University School of Medicine, Taegu, Korea.
- Publication Type:Case Report
- Keywords:
Prenatal diagnosis;
Congenital Wilms tumor;
NWTS-IV protocol
- MeSH:
Child;
Clinical Protocols;
Dactinomycin;
Early Diagnosis;
Female;
Fetus;
Follow-Up Studies;
Humans;
Mothers;
Nephrectomy;
Parturition;
Pregnant Women;
Prenatal Diagnosis*;
Prognosis;
Ultrasonography;
Ultrasonography, Prenatal;
Wilms Tumor*
- From:Korean Journal of Pediatric Hematology-Oncology
1998;5(1):202-206
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Early diagnosis of childhood cancer is very important for the prognosis. Ultrasonography of routine examination for pregnant woman is now a popular method. We experienced two cases of congenital Wilms tumor suspected by prenatal ultrasonography from mothers and confirmed by nephrectomy soon after birth. One of the cases was stage II with favorable histology and was treated with vincristine(2.0 mg/m2) and actinomycin D(45 microgram/kg) for 60 weeks by National Wilms Tumor Study(NWTS) IV treatment protocol, K-4 A regimen. The other was stage I with favorable histology and was treated with vincristine(1.5 mg/m2) and actinomycin D(15 microgram/kg) for 24 weeks by NWTS IV, EE regimen. The post-chemotherapy follow-up evaluation of these two children for 3 years and 2 months and 1 year and 7 months respectively were quite normal with 100% of Karnovsky scores. Early diagnosis, especially in prenatal, is very important for the prognosis of childhood cancer. Routine ultrasonographic examination in pregnant women is also desirable for the detection of solid tumor of fetus if it does not harmful for the fetus.
