Antiretroviral drug resistance among drug-naive HIV-1 infected patients.
- Author:
Seo Rin KIM
1
;
Eun Kyung RHEU
;
Young Mi SEOL
;
Dong Heuck CHA
;
Su Jin LEE
;
Yeun Kyung YOON
;
Soon Mi PARK
;
Heyung Hoe KIM
;
Hak Sun RHEU
;
Soon Chul AHN
;
Sun Hee LEE
;
Im Su KWAK
;
Goon Jae CHO
Author Information
1. Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. mdssampak@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
HIV;
Antiretroviral agent;
Drug resistance
- MeSH:
Cell Count;
Codon;
Drug Resistance*;
HIV;
HIV-1*;
Humans;
Korea;
Male;
Plasma;
Prevalence;
RNA;
RNA-Directed DNA Polymerase
- From:Korean Journal of Medicine
2007;73(3):243-250
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The prevalence of HIV drug resistance mutations in drug-naive patients has been shown to differ with geographic origin. The purpose of this study is to assess the prevalence of transmitted antiretroviral drug resistance mutations in drug-naive patients in Korea. METHODS: Genotypic resistance was determined by the use of the Viroseq Genotyping System in 42 antiretroviral treatment naive HIV-infected patients between March 2005 and July 2006. Transmitted drug resistance was estimated according to the IAS-USA 2005 definition, taking into account only major mutations in the protease and all mutations in the reverse transcriptase, including revertant mutations at codon 215. RESULTS: The median age of the patients was 42 years and 37 (88%) were male. The median CD4+T cell count was 136/mm3 and the mean plasma RNA level was 4.98 log copies/mL. Among 42 patients studied, 37 (88%) were newly diagnosed patients. None of the patients were recent seroconverters; 38 patients (90%) were infected with subtype B and 4 patients were infected (10%) with the non-B subtype strains (2 patients with CRF01-AE 1 as CRF02-AG; 1 patient with subtype A). Of the 42 subjects tested, we found 2 (4.8%) mutations in NRTI (V118I), but did not find a mutation in NNRTI as well as in the PI region. CONCLUSIONS: The prevalence of transmitted antiretroviral drug resistance in drug-naive patients is still low in Korean patients.
