Transformation of CD5-Negative Follicular Lymphoma into CD5-Positive Diffuse Large B-Cell Lymphoma: A Case Report.
- Author:
Hyeong Kug KIM
1
;
In Sung CHO
;
Hye Kyung LEE
;
Yong Hun CHOI
;
Seong Min CHO
;
Hyun Jin MOON
;
Jin A LEE
Author Information
1. Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea. cis@eulji.ac.kr
- Publication Type:Case Report
- Keywords:
Lymphoma, large B-cell, diffuse;
Lymphoma, follicular;
Cell transformation, neoplastic
- MeSH:
Antigens, Surface;
B-Lymphocytes;
Cell Transformation, Neoplastic;
Lymphoma;
Lymphoma, B-Cell;
Lymphoma, Follicular;
Lymphoma, Large B-Cell, Diffuse
- From:Korean Journal of Medicine
2012;83(2):263-267
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of aggressive lymphomas. Approximately 10% of DLBCL cases express CD5 as a surface antigen. CD5-positive DLBCL can occur as the de novo or secondary type. De novo CD5-positive DLBCL arises without previous lymphoproliferative disease, and secondary CD5-positive DLBCL may or may not manifest as Richter syndrome. The transformation of follicular lymphoma (FL) into DLBCL occurs in approximately one-third of all cases. The transformation of CD5-negative low-grade B-cell lymphoma to CD5-positive DLBCL is extremely rare. We report the clinical features of a rare case that presented with a transformation from CD5-negative FL to CD5-positive DLBL over 11 years. This is the second such case published in the English literature.
