Primary copper-associated chronic hepatitis without copper metabolism domain containing 1 mutation in a Dalmatian: a case report
- Author:
Sumin YUN
1
;
Dohee LEE
;
Jimin OH
;
Yeon CHAE
;
Taesik YUN
;
Yoonhoi KOO
;
Mhan-Pyo YANG
;
Byeong-Teck KANG
;
Hakhyun KIM
Author Information
- Publication Type:Case Report
- From:Korean Journal of Veterinary Research 2022;62(4):e31-
- CountryRepublic of Korea
- Language:English
- Abstract: A 12-year-old intact male Dalmatian dog presented hyporexia and vomiting for 1 week. Blood analysis revealed increased liver enzyme activity. Histopathological examination of the liver confirmed chronic hepatitis with fibrosis and necrosis. Copper staining revealed marked copper accumulation (2,770 ppm; normal range, 200 to 400 ppm), prominent in the centrilobular region, and compatible with copper-associated chronic hepatitis. However, copper metabolism domain containing 1 (COMMD1) mutation predisposing to copper accumulation in the liver tissue was not identified. The dog received medications but died 1 month after first visit. This is the first case of primary copper-associated hepatitis without COMMD1 mutation in a Dalmatian dog in South Korea.
