The anti-thrombotic activity of surfactins.
- Author:
Jong hwan LIM
1
;
Byung kwon PARK
;
Myoung seok KIM
;
Mi Hyun HWANG
;
Man Hee RHEE
;
Seung Chun PARK
;
Hyo in YUN
Author Information
1. College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea. hiyun@cnu.ac.kr
- Publication Type:Brief Communication
- Keywords:
anti-platelet aggregation;
platelet rich plasma;
surfactins
- MeSH:
Bacillus subtilis/metabolism;
Blood Platelets/drug effects;
Fibrinolytic Agents/*pharmacology;
Humans;
Peptides, Cyclic/isolation&purification/*pharmacology;
Platelet Aggregation Inhibitors/pharmacology
- From:Journal of Veterinary Science
2005;6(4):353-355
- CountryRepublic of Korea
- Language:English
-
Abstract:
Platelet aggregation was inhibited and the density of platelet-rich plasma (PRP) clots was decreased by the preincubation of PRP with surfactins, an acidic lipopeptide of Bacillus subtilis complex BC1212 isolated from soybean paste, in dose-dependent manner. Our findings suggest that surfactins are able to prevent a platelet aggregation leading to an inhibition of additional fibrin clot formation, and to enhance fibrinolysis with facilitated diffusion of fibrinolytic agents.
