Experimental reproduction of proliferative enteropathy and the role of IFN-gamma in protective immunity against Lawsonia intracellularis in mice.
- Author:
Yun Young GO
1
;
Jeong Keun LEE
;
Jeong Yong YE
;
Joong Bok LEE
;
Seung Yong PARK
;
Chang Seon SONG
;
Soo Ki KIM
;
In Soo CHOI
Author Information
1. Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea. ischoi@konkuk.ac.kr
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
IFN-gamma R- mice;
IFN-gamma;
Lawsonia intracellularis;
proliferative enteropathy
- MeSH:
Animals;
DNA, Viral;
Desulfovibrionaceae Infections/*immunology/microbiology;
Interferon Type II/*immunology;
Intestinal Diseases/*immunology/microbiology;
Intestinal Mucosa/immunology;
Lawsonia Bacteria/*immunology/isolation&purification;
Mice;
Mice, Knockout;
Polymerase Chain Reaction;
Receptors, Interferon/physiology
- From:Journal of Veterinary Science
2005;6(4):357-359
- CountryRepublic of Korea
- Language:English
-
Abstract:
Proliferative enteropathy was reproduced in IFN-gamma receptor knockout (IFN-gamma R-) mice by experimental infection with Lawsonia intracellularis (L. intracellularis). The cecum and the colon of the infected mice were evidently enlarged 2 weeks post infection. The presence of L. intracellularis was identified in the stool and the cecum of the mice after infection. However, high levels of IFN-gamma were detected in the sera of the infected mice 2 weeks PI. These data indicated that the IFN-gamma produced in the infected mice should have been utilized by it's receptor to elicit protective immune responses against L. intracellularis infections.
