Vitilligo Induced by Diphencyprone in a Patient with Alopecia Areata.
- Author:
Soo Jung KIM
;
Won Soo LEE
;
Seung Hun LEE
;
Sung Ku AHN
- Publication Type:Case Report
- Keywords:
Vitiligo;
DPCP(Diphencyrone)
- MeSH:
Alopecia Areata*;
Alopecia*;
Dermatitis;
Dermatitis, Contact;
Eyelashes;
Female;
Humans;
Phenol;
Pruritus;
Scalp;
Urticaria;
Vitiligo;
Young Adult
- From:Korean Journal of Dermatology
1994;32(5):934-938
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Common adverse effects due to topical therapy with DPCP(Diphenyprone) are severe contact dermatitis, dermographism, urticaria, generalized pruritus, lymphadenoiathy, and dermatitis on the remote areas. Rarely, DPCP can induce vitiligo or dyschromia in confetias side effects on the pigmentary system. It is not clear yet whither DPCP induced the vitiligcbatoxic effect of phenol ring in DPCP or by koebner phenomenon clue to repeated contact dermatitis in cases where vitiligo was in latent subclinical condition. We describe a patient with alopecia areatairho developed vitiligo due to topical therapy with DPCP. A 20-year-old woman developed alopecia areata with a loss of eye shows and eyelashes. After sensitization, DPCP was topically applieid to the scalp every week. Vitiligo, confirmed by electron microscopic study, appeared 4 month. after the beginning of treatment and was localized only to the areas of topical application. Both alogecia aieata and vitiligo are improving now under systemic and topical corticosteroid therapy.
