Effects of Volatile Anesthetics on Isolated Rings of Thoracic Aorta in Rats.
10.4097/kjae.1994.27.10.1229
- Author:
Young Ho CHO
1
;
Woon Yi BAEK
;
Jung Gil HONG
;
Jin Woong PARK
;
Byung Kwon KIM
Author Information
1. Department of Anesthesiology, School of Medicine, Kyungpook National University, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Inhalation anesthetics;
vasorelaxation;
EDRF
- MeSH:
Anesthetics*;
Anesthetics, Inhalation;
Animals;
Aorta, Thoracic*;
Endothelium;
Enflurane;
Halothane;
Isoflurane;
Muscle, Smooth, Vascular;
Phenylephrine;
Rats*;
Rats, Sprague-Dawley;
Relaxation;
Vasoconstriction;
Vasodilation;
Vasodilator Agents
- From:Korean Journal of Anesthesiology
1994;27(10):1229-1236
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Halothane, enflurane, and isoflurane are generally regarded as vasodilators. This property has been attributed to a direct action on vascular smooth muscle or the inhibition of vasoconstricition by endogenous neurohumoral substances. Because of the importance of the endothelium in determining of modulating the vascular responses of a wide vareity of agents, vascular effects of halothane, enflurane and isoflaurane on isolated rings of thoracic aorta in Sprague-Dawley rats were studied in the presence and absence of intact endothelium. Halothane, enflurane and isoflurane induced relaxation on thoraeic aortic rings precan-tracted with 50mM KCl both with and without endothelium. Halothane also induced vasodilation in both aortic rings precontracted with 10-6 M phenylephrine. And enflurane and isoflurane induced vasodilation in denuded aortic rings precontracted with phenylephrine. But endothelium intact rings demonstrsted significant(p<0.05) vasoconstriction at low concentrations of both enflurane and isoflurane followed by vasodilation at higher concentra- tion precontracted with phenyephrine. These results suggest that at low concentration and intact rings, enflurane and isoflurane eause vasoconstriction through inhibition of basal EDRF production and /or stimulation of the release of an endothelium derived constricting factor. At higher concentration, a direct vasodilating effect of the anesthetic predominance.
