Immunogenicity of SARS-CoV-2 Vaccine in Kidney Transplant Recipients:A Cross-Sectional Study in Korea
- Author:
Seung Hwan SONG
1
;
Ku Yong CHUNG
;
Yongho JEE
;
Hae-Sun CHUNG
;
Kina KIM
;
Dohsik MINN
;
Soo-Kyung KIM
Author Information
- Publication Type:Brief Communication
- From:Journal of Korean Medical Science 2023;38(5):e22-
- CountryRepublic of Korea
- Language:English
- Abstract: Eighty-five Korean kidney transplant recipients who received three doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine were tested with anti-receptor binding domain (RBD) antibody and neutralizing antibody. High anti-RBD antibody (≥ 100 U/mL) and neutralizing antibody responses (≥ 30%) were detected in 51/85 (60.0%) patients.When we divided the patients with the time from transplantation to vaccination (< 1, 1–2.4, 2.5–4.9, and ≥ 5-year), anti-RBD antibody titers were 3.2 U/mL, 27.8 U/mL, 370.2 U/mL, and 5,094.2 U/mL (P < 0.001) and anti-neutralizing antibody levels were 2.2%, 11.6%, 45.6%, and 93.0% (P < 0.001), respectively. Multivariate analysis revealed increased antibody responses when the time from transplantation to vaccination was five years or longer (odds ratio, 12.0; confidence interval, 2.7–52.8). Korean kidney transplant recipients had suboptimal antibody responses after the third dose of SARS-CoV-2 vaccine. A shorter time from transplantation to vaccination was a risk factor for a low antibody response.
