Real-world outcomes of niraparib treatment in patients with ovarian cancer: the first observational multicenter study in China
- Author:
Jin LI
1
;
Jianhua YANG
;
Huafeng SHOU
;
Lin ZHANG
;
Xiaohong HUANG
;
Xuedong TANG
;
Fei ZHENG
;
Fang LIU
;
Xiaohua WU
Author Information
- Publication Type:Young Doctor Session
- From:Journal of Gynecologic Oncology 2022;33(S1):S11-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:The objective of this study was to present the real-world patients’ portrait, and the results of niraparib treatment in China.
Methods:This study included 142 patients treated with niraparib from 8 hospitals in China between December 2018 and September 2021. Patients’ characteristics were summarized. The efficacy and safety in first-line maintenance (1L-M), platinum-sensitive recurrence maintenance (PSR-M), and treatment for ovarian cancer were evaluated. Survival outcomes and the factors influencing progression-free survival (PFS) were estimated.
Results:The 93 patients received Niraparib as 1L-M, 31 as PSR-M and 18 as salvage. BRCA status was wild type or unknown in 87.3% of patients. With a median follow-up time of 8.7 months, the median PFS (mPFS) for 1L-M has not yet been reached, and the mPFS for PSR-M and salvage therapy was 10.5 and 5.7 months, respectively. Responses to last chemotherapy and cancer antigen 125 value before taking niraparib were 2 important factors affecting PFS among 1L and PSR patients. The 12.7% (18/142) of patients experienced grade ≥3 hematologic adverse events and 23.2% experienced dose adjustment. It was noteworthy that when the interval of chemotherapy and niraparib <21 days, the incidence of grade ≥3 adverse events increased significantly (p=0.0355).
Conclusion:Generally, niraparib was effective and well tolerated, which was consistent with the results of prospective trials. However, in real world, it was more inclined to use niraparib in late-line treatment without genetic testing.
