Chronic Epstein-Barr virus infection causing both benign and malignant lymphoproliferative disorders.
10.3345/kjp.2014.57.9.420
- Author:
Yoojin KWUN
1
;
Soo Jong HONG
;
Jin Seong LEE
;
Da Hye SON
;
Jong Jin SEO
Author Information
1. Department of Pediatrics, Asan Medical Center, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea. jjseo@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
EBV infection;
Lymphoid interstitial pneumonia;
Burkitt's lymphoma
- MeSH:
Abdominal Pain;
Acyclovir;
Adolescent;
Ambulatory Care Facilities;
B-Lymphocytes;
Biopsy;
Bronchoalveolar Lavage;
Burkitt Lymphoma;
Child;
Cyclophosphamide;
Diagnosis;
Doxorubicin;
Drug Therapy, Combination;
Epstein-Barr Virus Infections;
Herpesvirus 4, Human*;
Humans;
In Situ Hybridization;
Lip;
Lung;
Lung Diseases, Interstitial;
Lymphoproliferative Disorders*;
Male;
Methotrexate;
Phenotype;
Physical Examination;
Pneumonia;
Prednisolone;
Vincristine
- From:Korean Journal of Pediatrics
2014;57(9):420-424
- CountryRepublic of Korea
- Language:English
-
Abstract:
The Epstein-Barr virus (EBV) is oncogenic and can transform B cells from a benign to a malignant phenotype. EBV infection is also associated with lymphoid interstitial pneumonia (LIP). Here, we report the case of a 14-year-old boy who was diagnosed with a latent EBV infection and underlying LIP, without any associated immunodeficiency. He had been EBV-seropositive for 8 years. The first clinical presentations were chronic respiratory symptoms and recurrent pneumonia. The symptoms worsened in the following 2 years. The results of in situ hybridization were positive for EBV, which led to a diagnosis of LIP. The diagnosis was confirmed by the results of a thoracoscopic lung biopsy. The EBV titer of the bronchoalveolar lavage specimens obtained after acyclovir treatment was found to be fluctuating. The patient had latent EBV infection for 8 years, until presented at the hospital with intermittent abdominal pain and distension. Physical examination and pelvic computed tomography revealed a large mesenteric mass. A biopsy of the excised mass led to a diagnosis of Burkitt's lymphoma (BL). The patient received combination chemotherapy for 4 months, consisting of vincristine, methotrexate, cyclophosphamide, doxorubicin, and prednisolone. He is now tumor-free, with the LIP under control, and is being followed-up at the outpatient clinic. This is the first report of a Korean case of chronic latent EBV infection that developed into LIP and BL in a nonimmunocompromised child.
