Expression of Involucrin and Filaggrin in Various Skin Disorders: Immunohistochemical Study.
- Author:
Seung Chul LEE
;
Jee Bum LEE
;
Jae Jeong SEO
;
Jin Young PARK
;
Young Ho WON
- Publication Type:Original Article
- Keywords:
Involucrin;
Filaggrin;
Keratinization;
Terminal differentiation
- MeSH:
Skin*
- From:Korean Journal of Dermatology
1999;37(6):708-714
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The cornified cell envelope (CE) is a unique structure found in the terminal differentiation of the skin. The precursor proteins of the CE are composed of many candidate structural proteins, among which invalucrin and filaggrin are important ones to participate in the complicated process of forming, the complex structure. OBJECTIVE: The purpose of this study was to evaluate the usefulness of expression of involucrin and filaggrin as markers of terminal differentiation in various skin disorders including tumors. METHODS: Immunohistochemical studies were performed in the formalin-fixed, paraffin-embedded skin samples of non-tumors (41 cases) and tumors (43 cases).
